The wolf in disguise: beyond humoral immunodeficiency

Wolf Reik: Inheritance beyond DNA

F or all it has given to science, Mendelian genetics is now a sim-plistic view of inheritance. On top of the DNA code lies another genetic " language, " the epigenetic code. Wolf Reik has built a career of decoding this language. Reik jumped on the now crowded epigenetic bandwagon when it was in its infancy, during both his PhD with Rudolf Jaenisch in Germany and his postdoc with Azim Surani in...

Primary Humoral Immunodeficiency : Optimizing IgG Replacement Therapy

Immunodeficiency with Autoimmunity: Beyond the Paradox

The association of immunodeficiency and autoimmunity may represent a paradox, yet it has been described in an increasing number of conditions. Use of unbiased genomic approach to identify novel forms of primary immunodeficiencies (PIDs), along with indepth functional studies in biological samples from affected individuals continue to unravel novel mechanisms underlying immune dysregulation in p...

Dualism in Disguise

The MDF discrimination measure: Fisher in disguise

Recently, a discrimination measure for feature extraction for two-class data, called the maximum discriminating (MDF) measure (Talukder and Casasent [Neural Networks 14 (2001) 1201-1218]), was introduced. In the present paper, it is shown that the MDF discrimination measure produces exactly the same results as the classical Fisher criterion, on the condition that the two prior probabilities are...